Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 85358
Gene Symbol: SHANK3
SHANK3 		0.110 CausalMutation disease CLINVAR Enhanced utility of family-centered diagnostic exome sequencing with inheritance model-based analysis: results from 500 unselected families with undiagnosed genetic conditions. 25356970 2015
Entrez Id: 6910
Gene Symbol: TBX5
TBX5 		0.100 CausalMutation disease CLINVAR
Entrez Id: 414
Gene Symbol: ARSD
ARSD 		0.100 AlteredExpression disease BEFREE One hundred children, aged 3-12 y, diagnosed as Autistic spectrum disorder; ASD (DSM-V) and 100 age and sex matched controls were studied. 31612302 2019
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2 		0.040 AlteredExpression disease BEFREE This case of ASD is of particular interest because despite the apparent lack of aldosterone synthase activity, the patient displays low-normal aldosterone levels, thus raising the question of its source. 15240589 2004
Entrez Id: 1401
Gene Symbol: CRP
CRP 		0.030 AlteredExpression disease BEFREE We examined the relationship between ASD severity and C-reactive protein levels in patients with acute myocardial infarction. 29243511 2018
Entrez Id: 1401
Gene Symbol: CRP
CRP 		0.030 AlteredExpression disease BEFREE Soluble IL-2 receptors, IL-4 and IL-18 levels were correlated with disease activity or CRP value only in chronic articular ASD. 11752512 2001
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.030 AlteredExpression disease BEFREE ASD symptom severity was negatively associated with levels of 4 cytokines, IL-1β, IL-8, MIP-1β, and VEGF, in females, but not in males. 29214007 2017
Entrez Id: 3606
Gene Symbol: IL18
IL18 		0.030 AlteredExpression disease BEFREE Soluble IL-2 receptors, IL-4 and IL-18 levels were correlated with disease activity or CRP value only in chronic articular ASD. 11752512 2001
Entrez Id: 3606
Gene Symbol: IL18
IL18 		0.030 AlteredExpression disease BEFREE Levels of IL-18 were found to correlate with serum ferritin values and disease severity in ASD. 11263769 2001
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8 		0.010 AlteredExpression disease BEFREE Interferon gamma and IL-8 remained increased only in chronic articular ASD, even when disease activity, including IL-6 and CRP, was low. 11752512 2001
Entrez Id: 1809
Gene Symbol: DPYSL3
DPYSL3 		0.010 AlteredExpression disease BEFREE Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism. 29196732 2017
Entrez Id: 51316
Gene Symbol: PLAC8
PLAC8 		0.010 AlteredExpression disease BEFREE DNA microarray and validation analysis using human monocytes revealed that the expression of PLAC8 was significantly higher in active-ASD patients than in inactive-ASD patients and healthy controls. 30404814 2018
Entrez Id: 3822
Gene Symbol: KLRC2
KLRC2 		0.010 AlteredExpression disease BEFREE Significant overexpression of NKG2C in hf-ASD patients (<i>p</i> = 0.0005), indicative of viral infections, was inversely correlated with the NKp46 receptor level (<i>r</i> = - 0.67; <i>p</i> < 0.0001), regardless of the IgG status of tested pathogens. 31123562 2019
Entrez Id: 847
Gene Symbol: CAT
CAT 		0.010 AlteredExpression disease BEFREE ASD significantly increased the expression of anti-oxidant enzymes (GSH, SOD, and CAT) in both liver and vascular tissue, reduced blood lipid levels (TG, TC, and LDL-C), and decreased lipid deposition in the liver and atherosclerotic lesion size in ApoE<sup>-/-</sup> mice. 30999121 2019
Entrez Id: 3565
Gene Symbol: IL4
IL4 		0.010 AlteredExpression disease BEFREE Soluble IL-2 receptors, IL-4 and IL-18 levels were correlated with disease activity or CRP value only in chronic articular ASD. 11752512 2001
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.010 AlteredExpression disease BEFREE ASD symptom severity was negatively associated with levels of 4 cytokines, IL-1β, IL-8, MIP-1β, and VEGF, in females, but not in males. 29214007 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.010 AlteredExpression disease BEFREE Immunofluorescence microscopy images showed a two times stronger expression of fluorescence in the ASD-treated group than in that treated with TGF-β1. 31474744 2019
Entrez Id: 9320
Gene Symbol: TRIP12
TRIP12 		0.300 Biomarker disease GENOMICS_ENGLAND CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors. 25294932 2014
Entrez Id: 23040
Gene Symbol: MYT1L
MYT1L 		0.300 Biomarker disease GENOMICS_ENGLAND CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors. 25294932 2014
Entrez Id: 55879
Gene Symbol: GABRQ
GABRQ 		0.300 Biomarker disease GENOMICS_ENGLAND Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability. 26350204 2015
Entrez Id: 4908
Gene Symbol: NTF3
NTF3 		0.200 Biomarker disease MGD LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. 19755105 2009
Entrez Id: 4908
Gene Symbol: NTF3
NTF3 		0.200 Biomarker disease MGD Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice. 9364058 1997
Entrez Id: 3491
Gene Symbol: CCN1
CCN1 		0.200 Biomarker disease MGD The matricellular protein CCN1 is essential for cardiac development. 17023674 2006
Entrez Id: 4908
Gene Symbol: NTF3
NTF3 		0.200 Biomarker disease MGD Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development. 8841198 1996
Entrez Id: 4908
Gene Symbol: NTF3
NTF3 		0.200 Biomarker disease MGD Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons. 7991545 1994